Manuel Carcao Selected Research

simoctocog alfa (Nuwiq)

10/2023	Simoctocog alfa (Nuwiq®) in previously untreated patients with severe haemophilia A-Final efficacy and safety results from the NuProtect study.
7/2023	Long-term immunogenicity, efficacy and tolerability of simoctocog alfa in patients with severe haemophilia A who had completed the NuProtect study in previously untreated patients.
11/2021	Simoctocog Alfa (Nuwiq) in Previously Untreated Patients with Severe Haemophilia A: Final Results of the NuProtect Study.

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Manuel Carcao Research Topics

Disease

39	Hemophilia A (Haemophilia) 03/2024 - 06/2006
22	Hemorrhage 02/2024 - 12/2003
5	Hemophilia B (Haemophilia B) 02/2024 - 11/2018
4	Factor XIII Deficiency 02/2022 - 05/2012
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 01/2020 - 12/2003
2	Anemia 10/2023 - 11/2003
2	Hemolysis 10/2023 - 01/2019
2	Joint Diseases (Joint Disease) 08/2022 - 06/2018
2	Headache (Headaches) 01/2022 - 01/2020
2	Seizures (Absence Seizure) 01/2022 - 06/2005
2	Intracranial Hemorrhages (Intracranial Hemorrhage) 01/2020 - 12/2003
2	Kaposiform Hemangioendothelioma 01/2020 - 11/2012
2	Thrombosis (Thrombus) 01/2016 - 05/2004
1	Respiratory Tract Infections (Respiratory Tract Infection) 10/2023
1	Hypersensitivity (Allergy) 07/2022
1	Pain (Aches) 07/2022
1	Vomiting 01/2022
1	Synovitis 10/2021
1	Pericardial Effusion 01/2020
1	Metrorrhagia (Spotting) 06/2018
1	Infections 06/2018
1	Hereditary Spherocytosis 05/2018
1	Hemarthrosis 02/2016
1	Hemangioma (Angioma) 06/2015
1	von Willebrand Diseases (von Willebrand's Disease) 06/2015
1	Hypothyroidism 06/2015
1	Purpura 12/2013
1	Menorrhagia 12/2013
1	Hemostatic Disorders 12/2013
1	Epistaxis (Nosebleed) 12/2013
1	Kasabach-Merritt Syndrome 11/2012
1	Tufted angioma 11/2012
1	Pure Red-Cell Aplasia 04/2008
1	Hematuria 09/2007
1	Leukemia 08/2006
1	Hyponatremia 06/2005
1	Communicable Diseases (Infectious Diseases) 12/2003
1	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 11/2003

Drug/Important Bio-Agent (IBA)

19	Factor VIII (Coagulation Factor VIII)IBA 02/2024 - 05/2013
6	Hemostatics (Antihemorrhagics)IBA 02/2024 - 05/2008
6	Blood Coagulation Factors (Coagulation Factor)IBA 11/2023 - 12/2013
5	emicizumabIBA 03/2024 - 01/2019
5	recombinant FVIIa (rFVIIa)FDA Link 02/2024 - 08/2006
5	Factor IX (Coagulation Factor IX)FDA LinkGeneric 02/2024 - 01/2016
4	nonacog beta pegolIBA 02/2024 - 11/2018
4	von Willebrand FactorIBA 08/2022 - 12/2013
3	factor VIII-Fc fusion proteinIBA 01/2024 - 01/2021
3	Factor VIIa (Activated Factor VII)IBA 01/2024 - 05/2008
3	BESIBA 10/2023 - 07/2022
3	simoctocog alfa (Nuwiq)IBA 10/2023 - 11/2021
3	Deamino Arginine Vasopressin (Desmopressin)FDA LinkGeneric 01/2022 - 06/2005
3	Intravenous Immunoglobulins (IVIG)FDA Link 01/2020 - 12/2003
2	Prothrombin (Factor II)IBA 01/2024 - 12/2015
2	SteroidsIBA 10/2023 - 06/2015
2	Blood Group Antigens (Blood Groups)IBA 10/2023 - 07/2021
2	AntibodiesIBA 01/2023 - 07/2022
2	Thrombin FDA Link 08/2022 - 01/2016
2	Monoclonal AntibodiesIBA 01/2021 - 01/2019
2	Inosine Triphosphate (ITP)IBA 01/2020 - 12/2003
2	Factor XIII (Coagulation Factor XIII)IBA 02/2017 - 05/2012
2	Adrenal Cortex Hormones (Corticosteroids)IBA 12/2003 - 11/2003
1	human F8 protein FDA Link 01/2024
1	AutoantibodiesIBA 10/2023
1	Proteins (Proteins, Gene)FDA Link 01/2023
1	Factor VII (Proconvertin)IBA 07/2022
1	hexanoic acid (hexanoate)IBA 05/2022
1	Tranexamic Acid (AMCA)FDA Link 05/2022
1	Antifibrinolytic Agents (Antifibrinolytics)IBA 05/2022
1	recombinant factor XIII-A2IBA 02/2022
1	Recombinant Fusion ProteinsIBA 11/2021
1	Heme (Haem)IBA 10/2021
1	HemosiderinIBA 10/2021
1	recombinant factor VIII N8IBA 01/2021
1	Sirolimus (Rapamycin)FDA Link 01/2020
1	IronIBA 01/2019
1	Von Willebrand antigenIBA 01/2016
1	iodothyronine deiodinase type III (type III deiodinase)IBA 06/2015
1	GlucocorticoidsIBA 06/2015
1	Vincristine (Oncovin)FDA LinkGeneric 06/2015
1	Thyroid HormonesIBA 06/2015
1	Adrenergic beta-Antagonists (beta-Adrenergic Blocking Agents)IBA 11/2012
1	Propranolol (Inderal)FDA LinkGeneric 11/2012
1	Valproic Acid (Depakote)FDA LinkGeneric 04/2008
1	Rituximab (Mabthera)FDA Link 06/2006
1	ElectrolytesIBA 06/2005
1	AnticoagulantsIBA 05/2004
1	Cyclosporine (Ciclosporin)FDA LinkGeneric 11/2003

Therapy/Procedure

20	Therapeutics 01/2024 - 11/2003
2	Splenectomy 05/2018 - 12/2003
2	Platelet Transfusion (Blood Platelet Transfusions) 09/2007 - 12/2003
2	Drug Therapy (Chemotherapy) 08/2006 - 05/2004
1	Blood Transfusion (Blood Transfusions) 01/2021
1	Central Venous Catheters 06/2018
1	HAD protocol 06/2018
1	Off-Label Use 05/2008
1	Intravenous Administration 06/2005
1	Plasma Exchange 05/2004